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Four distinct trajectories of tau deposition identified in Alzheimer’s disease
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- Vogel, Jacob W. (author)
- McGill University
-
- Young, A. L. (author)
- King's College London
-
- Oxtoby, N. P. (author)
- University College London
- show more...
- Weiner, M. (author)
- Aisen, P. (author)
- Petersen, R. (author)
- Jagust, W. (author)
- Trojanowki, J. Q. (author)
- Toga, A. W. (author)
- Beckett, L. (author)
- Green, R. C. (author)
- Saykin, A. J. (author)
- Morris, J. (author)
- Shaw, L. M. (author)
- Liu, E. (author)
- Montine, T. (author)
- Thomas, R. G. (author)
- Walter, S. (author)
- Gessert, D. (author)
- Sather, T. (author)
- Jiminez, G. (author)
- Harvey, D. (author)
- Bernstein, M. (author)
- Fox, N. (author)
- Thompson, P. (author)
- Schuff, N. (author)
- DeCarli, C. (author)
- Borowski, B. (author)
- Gunter, J. (author)
- Senjem, M. (author)
- Vemuri, P. (author)
- Jones, D. (author)
- Kantarci, K. (author)
- Ward, C. (author)
- Koeppe, R. A. (author)
- Foster, N. (author)
- Reiman, E. M. (author)
- Chen, K. (author)
- Mathis, C. (author)
- Landau, S. (author)
- Cairns, N. J. (author)
- Householder, E. (author)
- Reinwald, L. T. (author)
- Lee, V. (author)
- Korecka, M. (author)
- Figurski, M. (author)
- Crawford, K. (author)
- Neu, S. (author)
- Foroud, T. M. (author)
- Potkin, S. (author)
- Shen, L. (author)
- Kelley, F. (author)
- Kim, S. (author)
- Nho, K. (author)
- Kachaturian, Z. (author)
- Frank, R. (author)
- Snyder, P. J. (author)
- Molchan, S. (author)
- Kaye, J. (author)
- Quinn, J. (author)
- Lind, B. (author)
- Carter, R. (author)
- Dolen, S. (author)
- Schneider, L. S. (author)
- Pawluczyk, S. (author)
- Beccera, M. (author)
- Teodoro, L. (author)
- Spann, B. M. (author)
- Brewer, J. (author)
- Vanderswag, H. (author)
- Fleisher, A. (author)
- Heidebrink, J. L. (author)
- Lord, J. L. (author)
- Mason, S. S. (author)
- Albers, C. S. (author)
- Knopman, D. (author)
- Johnson, K. (author)
- Doody, R. S. (author)
- Meyer, J. V. (author)
- Chowdhury, M. (author)
- Rountree, S. (author)
- Dang, M. (author)
- Stern, Y. (author)
- Honig, L. S. (author)
- Bell, K. L. (author)
- Ances, B. (author)
- Morris, J. C. (author)
- Carroll, M. (author)
- Leon, S. (author)
- Mintun, M. A. (author)
- Schneider, S. (author)
- Oliver, A. (author)
- Griffith, R. (author)
- Geldmacher, D. (author)
- Brockington, J. (author)
- Roberson, E. (author)
- Grossman, H. (author)
- Mitsis, E. (author)
- deToledo-Morrell, L. (author)
- Shah, R. C. (author)
- Varon, D. (author)
- Greig, M. T. (author)
- Roberts, P. (author)
- Albert, M. (author)
- Onyike, C. (author)
- D’Agostino, II (author)
- Kielb, S. (author)
- Galvin, J. E. (author)
- Pogorelec, D. M. (author)
- Cerbone, B. (author)
- Michel, C. A. (author)
- Rusinek, H. (author)
- de Leon, M. J. (author)
- Glodzik, L. (author)
- De Santi, S. (author)
- Doraiswamy, P. M. (author)
- Petrella, J. R. (author)
- Wong, T. Z. (author)
- Arnold, S. E. (author)
- Karlawish, J. H. (author)
- Wolk, D. (author)
- Smith, C. D. (author)
- Jicha, G. (author)
- Hardy, P. (author)
- Sinha, P. (author)
- Oates, E. (author)
- Conrad, G. (author)
- Lopez, O. L. (author)
- Oakley, M. A. (author)
- Simpson, D. M. (author)
- Porsteinsson, A. P. (author)
- Goldstein, B. S. (author)
- Martin, K. (author)
- Makino, K. M. (author)
- Ismail, M. S. (author)
- Brand, C. (author)
- Mulnard, R. A. (author)
- Thai, G. (author)
- McAdams Ortiz, C. (author)
- Womack, K. (author)
- Mathews, D. (author)
- Quiceno, M. (author)
- Arrastia, R. D. (author)
- King, R. (author)
- Weiner, M. (author)
- Cook, K. M. (author)
- DeVous, M. (author)
- Levey, A. I. (author)
- Lah, J. J. (author)
- Cellar, J. S. (author)
- Burns, J. M. (author)
- Anderson, H. S. (author)
- Swerdlow, R. H. (author)
- Apostolova, L. (author)
- Tingus, K. (author)
- Woo, E. (author)
- Silverman, D. H. S. (author)
- Lu, P. H. (author)
- Bartzokis, G. (author)
- Radford, N. R. G. (author)
- Parfitt, F. (author)
- Kendall, T. (author)
- Johnson, H. (author)
- Farlow, M. R. (author)
- Hake, A. M. (author)
- Matthews, B. R. (author)
- Herring, S. (author)
- Hunt, C. (author)
- van Dyck, C. H. (author)
- Carson, R. E. (author)
- MacAvoy, M. G. (author)
- Chertkow, H. (author)
- Bergman, H. (author)
- Hosein, C. (author)
- Black, S. (author)
- Stefanovic, B. (author)
- Hsiung, G. Y. R. (author)
- Feldman, H. (author)
- Mudge, B. (author)
- Past, M. A. (author)
- Kertesz, A. (author)
- Rogers, J. (author)
- Trost, D. (author)
- Bernick, C. (author)
- Munic, D. (author)
- Kerwin, D. (author)
- Mesulam, M. M. (author)
- Lipowski, K. (author)
- Wu, C. K. (author)
- Johnson, N. (author)
- Sadowsky, C. (author)
- Martinez, W. (author)
- Villena, T. (author)
- Turner, R. S. (author)
- Johnson, K. (author)
- Reynolds, B. (author)
- Sperling, R. A. (author)
- Johnson, K. A. (author)
- Marshall, G. (author)
- Frey, M. (author)
- Yesavage, J. (author)
- Taylor, J. L. (author)
- Lane, B. (author)
- Rosen, A. (author)
- Tinklenberg, J. (author)
- Sabbagh, M. N. (author)
- Belden, C. M. (author)
- Jacobson, S. A. (author)
- Sirrel, S. A. (author)
- Kowall, N. (author)
- Killiany, R. (author)
- Budson, A. E. (author)
- Norbash, A. (author)
- Johnson, P. L. (author)
- Obisesan, T. O. (author)
- Wolday, S. (author)
- Allard, J. (author)
- Lerner, A. (author)
- Ogrocki, P. (author)
- Hudson, L. (author)
- Fletcher, E. (author)
- Carmichael, O. (author)
- Olichney, J. (author)
- DeCarli, C. (author)
- Kittur, S. (author)
- Borrie, M. (author)
- Lee, T. Y. (author)
- Bartha, R. (author)
- Johnson, S. (author)
- Asthana, S. (author)
- Carlsson, C. M. (author)
- Potkin, S. G. (author)
- Preda, A. (author)
- Nguyen, D. (author)
- Tariot, P. (author)
- Reeder, S. (author)
- Bates, V. (author)
- Capote, H. (author)
- Rainka, M. (author)
- Scharre, D. W. (author)
- Kataki, M. (author)
- Adeli, A. (author)
- Zimmerman, E. A. (author)
- Celmins, D. (author)
- Brown, A. D. (author)
- Pearlson, G. D. (author)
- Blank, K. (author)
- Anderson, K. (author)
- Santulli, R. B. (author)
- Kitzmiller, T. J. (author)
- Schwartz, E. S. (author)
- Sink, K. M. (author)
- Williamson, J. D. (author)
- Garg, P. (author)
- Watkins, F. (author)
- Ott, B. R. (author)
- Querfurth, H. (author)
- Tremont, G. (author)
- Salloway, S. (author)
- Malloy, P. (author)
- Correia, S. (author)
- Rosen, H. J. (author)
- Miller, B. L. (author)
- Mintzer, J. (author)
- Spicer, K. (author)
- Bachman, D. (author)
- Finger, E. (author)
- Pasternak, S. (author)
- Rachinsky, I. (author)
- Drost, D. (author)
- Pomara, N. (author)
- Hernando, R. (author)
- Sarrael, A. (author)
- Schultz, S. K. (author)
- Ponto, L. L. B. (author)
- Shim, H. (author)
- Smith, K. E. (author)
- Relkin, N. (author)
- Chaing, G. (author)
- Raudin, L. (author)
- Smith, A. (author)
- Fargher, K. (author)
- Raj, B. A. (author)
- Pontecorvo, M. J. (author)
- Devous, M. D. (author)
- Rabinovici, G. D. (author)
- Alexander, D. C. (author)
- Evans, A. C. (author)
- show less...
- (creator_code:org_t)
- 2021-04-29
- 2021
- English.
- In: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 27:5, s. 871-881
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Alzheimer’s disease (AD) is characterized by the spread of tau pathology throughout the cerebral cortex. This spreading pattern was thought to be fairly consistent across individuals, although recent work has demonstrated substantial variability in the population with AD. Using tau-positron emission tomography scans from 1,612 individuals, we identified 4 distinct spatiotemporal trajectories of tau pathology, ranging in prevalence from 18 to 33%. We replicated previously described limbic-predominant and medial temporal lobe-sparing patterns, while also discovering posterior and lateral temporal patterns resembling atypical clinical variants of AD. These ‘subtypes’ were stable during longitudinal follow-up and were replicated in a separate sample using a different radiotracer. The subtypes presented with distinct demographic and cognitive profiles and differing longitudinal outcomes. Additionally, network diffusion models implied that pathology originates and spreads through distinct corticolimbic networks in the different subtypes. Together, our results suggest that variation in tau pathology is common and systematic, perhaps warranting a re-examination of the notion of ‘typical AD’ and a revisiting of tau pathological staging. © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
- Vogel, Jacob W.
- Young, A. L.
- Oxtoby, N. P.
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- Thomas, R. G.
- Donohue, M.
- Walter, S.
- Gessert, D.
- Sather, T.
- Jiminez, G.
- Harvey, D.
- Bernstein, M.
- Fox, N.
- Thompson, P.
- Schuff, N.
- DeCarli, C.
- Borowski, B.
- Gunter, J.
- Senjem, M.
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- Jones, D.
- Kantarci, K.
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- Bell, K. L.
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- Pogorelec, D. M.
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- Rusinek, H.
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- Doraiswamy, P. M ...
- Petrella, J. R.
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- Hardy, P.
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- MacAvoy, M. G.
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- Wu, C. K.
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- Sadowsky, C.
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- Villena, T.
- Turner, R. S.
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- Sperling, R. A.
- Johnson, K. A.
- Marshall, G.
- Frey, M.
- Yesavage, J.
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- Lane, B.
- Rosen, A.
- Tinklenberg, J.
- Sabbagh, M. N.
- Belden, C. M.
- Jacobson, S. A.
- Sirrel, S. A.
- Kowall, N.
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- Budson, A. E.
- Norbash, A.
- Johnson, P. L.
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- Wolday, S.
- Allard, J.
- Lerner, A.
- Ogrocki, P.
- Hudson, L.
- Fletcher, E.
- Carmichael, O.
- Olichney, J.
- Kittur, S.
- Borrie, M.
- Lee, T. Y.
- Bartha, R.
- Johnson, S.
- Asthana, S.
- Carlsson, C. M.
- Potkin, S. G.
- Preda, A.
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- Capote, H.
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- Bachman, D.
- Finger, E.
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- Drost, D.
- Pomara, N.
- Hernando, R.
- Sarrael, A.
- Schultz, S. K.
- Ponto, L. L. B.
- Shim, H.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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